Thioamide drugs

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Actual: As new biological functions are uncovered for natural thioamides, these can inform the use of thioamides in a designed fashion, leading to applications beyond the current directions of improving the stability and activity of peptide drugs. Of course, the study of thioamide-containing peptides and proteins in biophysical and medicinal chemistry
4.4 rating 2025-04-24
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thioamides into other carbonyl derivatives.14 The differences in amide and thioamide geometry govern many of the non-covalent interactions exhibited by thioamide-containing peptides. The thioamide C=S bond is 1/3 longer than the amide C=O bond (1.71 vs. 1.23 )15 and sulfur has a

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Thioamides. Drugs. methimazole. first-line thioamide. propylthiouracil (PTU). used only in pregnant patients, breastfeeding patients, and

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by SK Hadjikakou 2024This presentation is a brief review on the results of our work on iodine interaction with thioamides, selenoamides and amides. The thioamides

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thioamide drugs. Two molecules of DIT combine within the thyroglobulin The thioamides methimazole and propylthiouracil are major drugs for treatment of

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Propylthiouracil or PTU Trade Names: (generic), PTU Drug Class: Antithyroid (Thioamide) Mechanisms of Action: Indications:.

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Ther. Class. antithyroid agents. Pharm. Class. thioamides

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by JJ Lipsky 2024 Cited by 20Article MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA was published on Decem in the journal Drug

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8.1 Antithyroid Drugs (Thioamides) Drugs Propylthiouracil, methimazole, carbimazole. Mechanism of action thioamides inhibit the TPO enzyme and thereby produce the following effects: Inhibition of iodination of tyrosine residues of thyroglobulin. Inhibition of coupling of iodotyrosyl residues to form iodothyronines

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Both drugs can traverse the placenta, potentially causing neonatal hypothyroidism. Propylthiouracil and methimazole are classified as thioamides.

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