Warfarin TMP-SMX - supratherapeutic INR and bleeding. Macrolides interact with statins, calcium channel blockers and quinolones.
We observed that the majority of patients with supratherapeutic INR had their INR values between 3.2 and 3.9. Elderly patients, with higher HAS-BLED scores and prolonged duration of warfarin therapy, were observed with an increased risk of supratherapeutic anticoagulation. Careful dosage modificatio
The mean age of enrolled patients was 69 years, and the mean INR at enrollment was 5.8 to 6.0 among the 724 enrolled patients. 3 Supratherapeutic INR values
by YS Alakeel 2024The incidence of a subtherapeutic or supratherapeutic INR was independent of demographic or clinical variables. definition of stable INR. We excluded
by I Safatly Cited by 2therapy presenting to the ED with a supratherapeutic INR with or without bleeding, stipulating the treatment Continuous data were reported using mean (
Individual patient circumstances may mean that practice diverges from this LOP. Search for the reason(s) for supratherapeutic INR. INR greater
by A Holbrook 2024 Cited by 1588When the INR is supratherapeutic without evidence of bleeding, strategies INR, 5 in 95% vs 45% of patients and a mean INR of 3.7 vs 5.4 at 24 h
General principles for preventing supratherapeutic INR involve careful monitoring and consideration of warfarin-drug interactions, including avoiding
In addition, warfarin doses and international normalized ratio (INR) values were calculated week-by-week after the initiation of amiodarone. Results The initiation of amiodarone increased the mean INR from 2.6 to 3.1. The proportion of patients with a supratherapeutic INR over 3.0 and 4.0 increased from 12% to 37% and 0.9% to 5.5%, respectively.
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