Leucovorin and methotrexate

Leucovorin rescue4 is required in some methotrexate regimens. Methotrexate dose: ▫ 500 mg/m2 requires leucovorin rescue. ▫ mg/m2 may

Leucovorin is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to treat certain

Leucovorin should not be administered concurrently with methotrexate. It is commonly initiated 24 hours after the start of methotrexate. Toxicity to normal

Leucovorin for methotrexate and 5-FU for methotrexate: rescue theapy for 5-FU a final cinfirmation 【Reference and figure】

High-Dose Methotrexate, Leucovorin and Glucarpidase Dosing, Administration, and Monitoring - Adult/Pediatric - Inpatient

Leucovorin Rescue after High-Dose Methotrexate Therapy. The recommendations for leucovorin rescue are based on a methotrexate dose of 12 to 15 grams/m2 administered by intravenous infusion over 4 hours (see methotrexate package insert for full prescribing information).

Methotrexate rescue is a technique used in cancer chemotherapy. The technique involves the admininstration of leucovorin after high dose methotrexate treatment.

Leucovorin should be given 2 3 hours after glucarpidase, then every 3 6 hours at doses guided by the methotrexate concentration (pharmacokinetically guided dosing; Fig. 3) . Reduction of the plasma methotrexate concentration reduces the competition between methotrexate and leucovorin for intracellular access.

Leucovorin has no effect on other established toxicities of methotrexate such as nephrotoxicity and/or metabolite precipitation in the kidney.