Drugs that cause thrombocytosis

Miconazole has been implicated in causing thrombocytosis and has a documented case validated by drug rechallenge. Iron, predictably, can cause a transient thrombocytosis. The beta-lactam antibiotic data are very difficult to interpret due to the possibility of an acute-phase reaction in an infected patient being the cause of the thrombocytosis.

Reactive thrombocytosis (RT), also known as secondary thrombocytosis, is a proliferation of platelets caused by a response to growth factors.

The causes of thrombocytosis have been reported in several studies. However, to our knowledge, this is the largest study to date analyzing the causes of thrombocytosis defined by a platelet count of ＞450 10 9 /L in adults. In our study, we identified 150 patients (12.5%) with primary thrombocytosis in the total cohort of 1,202 patients with

Only 1 study specifically categorized drug-induced causes of thrombocytosis, recording an incidence of 3% of all sec-ondary thrombocytosis.6 The other studies evaluating the

Secondary thrombocytosis, also called reactive thrombocytosis Certain antipsychotic drugs; Certain acne medications; Epinephrine

Drugs. Drug-induced thrombocytosis can result from various causative factors. One proposed mechanism is that certain drugs can cause the release of cytokines, particularly IL6, leading to thrombocytosis. The increased IL6 would then lead to thrombocytosis. Many drugs can induce thrombocytosis, with varying propensities to do so.

Data Synthesis: Drug-induced thrombocytosis, a form of reactive thrombocytosis cannot be easily differentiated from more common etiologies of reactive thrombocytosis. In all, 43 case reports of drug-induced thrombocytosis from a wide variety of drugs and drug classes were reviewed using a modified Naranjo probability scale that included

Reactive thrombocytosis (RT) Most common cause of thrombocytosis, accounting for 85% of cases. A reaction to another process, such as inflammation, infection, cancer, or iron deficiency. Rarely causes complications even with extremely elevated platelet counts ( 1,000,000/microL). Autonomous thrombocytosis (AT) Accounts for 15% of cases

Drugs. Drug-induced thrombocytosis can result from various causative factors. One proposed mechanism is that certain drugs can cause the release of cytokines, particularly IL6, leading to thrombocytosis. The increased IL6 would then lead to thrombocytosis. Many drugs can induce thrombocytosis, with varying propensities to do so.