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Author: Admin | 2025-04-28
Treated with CERENIA Tablets and in 83% (10 of 12) of Beagle dogs treated with placebo tablets. In a study of 275 canine patients presented to veterinary hospitals with a history of acute vomiting, dogs were initially administered CERENIA Injectable Solution or placebo on Day 0. Following the initial dose, dogs allocated to the CERENIA group were treated with either CERENIA Tablets at a minimum of 2 mg/kg orally or Injectable Solution at 1 mg/kg subcutaneously once daily at the discretion of the clinician. Dogs allocated to the placebo group were treated using either an injectable placebo solution or placebo tablets once daily at the discretion of the clinician. Of the 199 dogs included in the analysis for effectiveness, 27 of 54 dogs (50%) in the placebo group displayed vomiting at some time during the study and 31 of 145 dogs (21.4%) in the treated group displayed vomiting during the study period. Percent Of Vomiting For Each Study Day, Based Upon Treatment And Route Of Administration. DaysTreatmentRoute# dogs# vomited% vomited * 2 dogs administered CERENIA were not observed on day 0. Their vomiting status was unknown. 143 was used in the denominator for % vomited. Day 0Placebo (54)SC541528% CERENIA (145)SC145 (143*)1410% Day 1Placebo (45)PO22314% SC231670% CERENIA (108)PO6723% SC411639% Day 2Placebo (16)PO7229% SC9667% CERENIA (37)PO2400% SC13862% Day 3Placebo (6)PO200% SC4125% CERENIA (21)PO1400% SC7571% Day 4Placebo (2)PO100% SC11100% CERENIA (7)PO500% SC2150% Day 5CERENIA (1)SC100% Prevention of Vomiting due to Motion Sickness In a study of canine veterinary patients taken on a one-hour car journey and treated with either CERENIA Tablets at a minimum dose of 8 mg/kg BW or placebo tablets 2 hours prior to the journey, 67 of 122 (55%) of dogs vomited during the journey when treated with placebo while 8 of 122 (7%) vomited during the journey after treatment with CERENIA Tablets. The probability that a dog in this study, prone to motion sickness would NOT vomit during a journey if treated with CERENIA Tablets was 93%, while the probability was 48% if treated with placebo. ANIMAL SAFETY Laboratory and field studies have demonstrated that CERENIA Tablets are well
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