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Author: Admin | 2025-04-28
8-mg dose group was significantly better than in the 1-mg dose group (p=.00041) and in the 3-mg dose group (p=.045); other comparison (1 mg dose with 3 mg dose) was not significant. Methadone group was significantly better than 1mg buprenorphine dose group (p=.004), but was not significantly different from 3 mg buprenorphine dose group (p=.18) or 8 mg buprenorphine dose group (p=.49). The results support the efficacy of buprenorphine for outpatient treatment of heroin dependence and seem to indicate that the highest dose (8 mg) of buprenorphine was the best of the three doses of buprenorphine, and also support the superiority of 30 mg of methadone compared to 1 mg dose of buprenorphine for Iranian heroin-dependent patients to increase their retention in treatment.Douglas S. Goldsmith Dana HuntDouglas S. LiptonDavid L. StrugIn the Tri-State Ethnographic Project (TRISEP) we found many of the same side effects ascribed to methadone as reported in the clinical literature: constipation, body aches and bone problems, sweating, sexual problems, weight changes, stomach distress, drowsiness and insomnia. Clinical evidence suggests that many reported symptoms may be related to dosage acclimation, interaction of methadone with other drugs, detoxification effects or problems undiagnosed during addiction. Clients of methadone maintenance treatment programs have explanations of the side effects of methadone that arise from the needs of clients to understand and control their physical condition, and from experiences which they bring from the addict world where self-management of medication is the norm. Information shared among clients about how to interpret and manage side effects produces client home remedies, including innocuous regimens such as vitamins or exercise, as well as harmful practices such as the use of cocaine or sedatives a...William R. MartinMethadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent to morphine when both are administered subcutaneously and one half as potent when administered orally. Chronically administered methadone produces sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution, and edema. Even when patients were receiving and tolerant to 100 mg/day, drug-seeking behavior was seen. Methadone hydrochloride in dose level of 100 mg orally produces physical dependence similar to that produced by morphine, except that onset of the abstinence syndrome is slower. The abstinence syndrome may be of moderate or severe intensity and is qualitatively similar to morphine abstinence syndrome. As in morphine-dependent subjects, the acute abstinence syndrome of methadone-dependent subjects is followed by a protracted abstinence syndrome.James L. MathisHeroin addiction as a major social, legal and medical problem, should be viewed in the sexual aspect as it is," rather than through a mythological mist of half truths. (Author)Background. The unique pharmacological properties of buprenorphine may make it a useful maintenance therapy for opiate addiction. This meta-analysis considers the effectiveness of buprenorphine relative to methadone. Methods. A systematic literature search identified five randomized clinical trials comparing buprenorphine to methadone. Data from these trials were obtained. Retention in treatment was analyzed with a Cox proportional hazards regression. Urinalyses for opiates were studied with analysis of variance and
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